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Recombinant Sheep IL-1RA Protein

Placeholder Recombinant Human TNFa Protein
Placeholder Recombinant Canine IL-8 Protein
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$99.00 – $456.00

DataSheet   

The recombinant sheep IL-1RA protein is derived from in vitro expression of sheep IL-1RA gene in E. coli and purified using his-tag affinity column and can be used in multiple applications such as cell culture, ELISA and western blot.

Alternative names for IL-1RA: Interleukin 1 receptor antagonist

This product is for Laboratory Research Use Only not for diagnostic and therapeutic purposes or any other purposes.

CAT: GR104075 Categories: , ,
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Description

Genorise Recombinant Sheep IL-1RA Protein Summary

Alternative names for IL-1RA: Interkeukin 1 receptor antagonist

 

Product Specifications

Purity > 96%, by SDSPAGE under reducing conditions and visualized by silver stain.
Endotoxin Level < 0.1 EU per 1 μg of the protein by the LAL method.
Activity Measured by its ability to inhibit IL-1a-dependent proliferation in D10.G4.1 mouse helper T cells. The ED50 for this effect is 5-40 ng/ml in the presence of 50 pg/ml of rhIL-1a.

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Source E. coli derived sheep IL-1RA.
Accession # W5QI35
N-Terminal Sequence Analysis Thr
Amino Acid Sequence Thr21-Asp174
Predicted Molecular Mass 17 kDa
SDS-PAGE 17 kDa, reducing conditions

 

Background: 

IL1ra is secreted by various types of cells including immune cells, epithelial cells, and adipocytes, and is a natural inhibitor of the pro-inflammatory effect of IL1β (1). This protein binds non-productively to the cell surface interleukin-1 receptor (IL-1R), and inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1β), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. Four alternatively spliced transcript variants encoding distinct isoforms have been reported (2). A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Mutations in the IL1ra gene results in a rare disease called deficiency of the interleukin-1–receptor antagonist (DIRA). Variants of the IL1ra gene is also associated with risk of schizophrenia. Elevated levels of IL1RNra  has been found in serum of schizophrenia patients. An interleukin 1 receptor antagonist is used in the treatment of rheumatoid arthritis, an autoimmune disease in which IL-1 plays a key role.

References

  1. Perrier S, et al. (2006). FEBS Lett. 580(27):6289.
  2. Entrez Gene: IL1RN interleukin 1 receptor antagonist.

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