Recombinant Sheep BMP4 Protein
$99.00 – $456.00
DataSheet Â
The recombinant sheep BMP4 protein is derived from in vitro expression of sheep BMP4 gene in E. coli and purified using his-tag affinity column and can be used in multiple applications such as cell culture, ELISA and western blot.
Alternative names for BMP4: Bone morphogenetic protein 4
This product is for Laboratory Research Use Only not for diagnostic and therapeutic purposes or any other purposes.
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Description
Genorise Recombinant Sheep BMP4 Protein Summary
Alternative names for BMP4: Bone morphogenetic protein 4
Alternative name for sheep: ovine, lamb, goat
Product Specifications
| Purity | > 96%, by SDSPAGE under reducing conditions and visualized by silver stain. |
| Endotoxin Level | < 0.1 EU per 1 μg of the protein by the LAL method. |
| Activity | Measured in a cell proliferation assay using HUVEC human umbilical vein endothelial cells. Conn, G. et al. (1990) Proc Natl Acad Sci USA 87:1323. The ED50 for this effect is typically 15-38 ng/mL. |
| Source | E. coli derived sheep BMP4. |
| Accession # | NP_001103747.1 |
| N-Terminal Sequence Analysis | Ser |
| Amino Acid Sequence | Ser294-His409 |
| Predicted Molecular Mass | 13 kDa |
| SDS-PAGE | 13 kDa, reducing conditions |
Background:Â
Bone morphogenetic protein 4 (BMP4) is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. This particular family member plays an important role in the onset of endochondral bone formation in humans. It has been shown to be involved in muscle development, bone mineralization, and uteric bud development. In human embryonic development, BMP4 is a critical signaling molecule required for the early differentiation of the embryo and establishing of a dorsal-ventral axis. BMP4 is secreted from the dorsal portion of the notochord, and it acts in concert with sonic hedgehog (released from the ventral portion of the notochord) to establish a dorsal-ventral axis for the differentiation of later structures.BMP4 stimulates differentiation of overlying ectodermal tissue.BMP4 has also been implicated in Fibrodysplasia Ossificans Progressiva in which it is overexpressed (1). Increase in expression of BMP4 has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva.
References
- Kan L, et al. (2004). Am. J. Pathol. 165 (4): 1107
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