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Recombinant Rabbit TGFb3 Protein

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DataSheet   

The recombinant rabbit TGFb3 protein is derived from in vitro expression of rabbit TGFb3 gene in E. coli and purified using his-tag affinity column and can be used in multiple applications such as cell culture, ELISA and western blot.

Alternative names for TGFb3: transforming growth factor beta 3

This product is for Laboratory Research Use Only not for diagnostic and therapeutic purposes or any other purposes.

CAT: GR104251 Categories: , Tag:
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Description

Genorise Recombinant Rabbit TGFb3 Protein Summary

Alternative names for TGFb3: transforming growth factor beta 3

Product Specifications

Purity > 96%, by SDSPAGE under reducing conditions and visualized by silver stain.
Endotoxin Level < 0.1 EU per 1 μg of the protein by the LAL method.
Activity Measured by its ability to inhibit the IL-4-dependent proliferation of HT-2 mouse T cells. Tsang, M et al. (1995) 7:389. The ED50 for this effect is typically 40-200 pg/mL.
Source E. coli derived rabbit TGFb3.
Accession # G1T192
N-Terminal Sequence Analysis Ala
Amino Acid Sequence Ala192 –Ser303
Predicted Molecular Mass 13 kDa
SDS-PAGE 13 kDa, reducing conditions

 

Background: 

Transforming growth factor, beta 3 (TGF-b3) belongs to a large family of cytokines called the Transforming growth factor beta super family (1, 2), which includes the TGF-β family, bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs), inhibins and activins. TGF-β3 is expressed in numerous cells including epithelial cells (3). TGF-β3 is a Ser/Thr protein kinase and is believed to regulate molecules involved in cellular adhesion and extracellular matrix (ECM) formation during the process of palate development. Without TGF-β3, mammals develop a deformity known as a cleft palate (4). This is caused by failure of epithelial cells in both sides of the developing palate to fuse. TGF-b3 is involved in embryogenesis and cell differentiation. TGF-b3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate development (5). TGF-b3 functions in normal palate and lung morphogenesis and is implicated in epithelial-mesenchymal interaction (4). Together with other members of TGF-b, TGF-β3 functions via endoglin, an accessory protein that interacts with the receptors of the TGF-β family (6); TGF-b3 has interaction with the type I receptor ALK-1 (7).

References

  1. ten Dijk P. et al. (1988) Proc. Natl. Acad. Sci. 85: 4715-9.
  2. Derynck R. et al. (1989) EMBO J. 7:3737-43.
  3. Djonov V. et al. (1997) Prostate 31: 103-9.
  4. Kaartinen V. et al. (1995) Nature Genet. 11: 415-21.
  5. Nawshad A. et al. (20030 J. Cell Biol. 163: 1291-1301.
  6. Barbara NP et al. (1999) J. Biol. Chem. 274: 584-94.
  7. Lux A et al. (1999) J. Biol. Chem. 274: 9984-92.

 

 

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