Description

Genorise Recombinant Rabbit IL-6R Protein Summary

Alternative names for IL-6R: Interleukin IL-6 receptor, IL6R

Product Specifications

Background: 

Interleukin 6 receptor (IL6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. In melanocytic cells IL6R gene expression may be regulated by MITF.^[1] The IL6 receptor is a protein complex consisting of a IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. IL6R also denotes the human gene encoding this subunit. Alternatively spliced transcript variants encoding distinct isoforms have been reported.^[2] IL6R subunit is also shared by many other cytokines. Interleukin-6 receptor has been shown to interact with Interleukin 6^{[2] [3] [4]} and Ciliary neurotrophic factor.^[3][5]

Reference

1. Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). Pigment Cell Melanoma Res. 21 (6): 665–76.
2. Schwantner, Andreas et al. (2004) J. Biol. Chem. 279 (1): 571–6.
3. Schuster, Björn et al. (2003) J. Biol. Chem. 278 (11): 9528–35.
4. Taga, T et al. (1989) Cell 58 (3): 573–81.
5. Schooltink, H (1992) FEBS Lett. 314 (3): 280–4.

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