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Recombinant Monkey GDF-15 Protein

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DataSheet   

The recombinant monkey GDF-15 protein is derived from in vitro expression of monkey GDF-15 gene in E. coli and purified using his-tag affinity column and can be used in multiple applications such as cell culture, ELISA and western blot.

Alternative names for GDF-15: Growth differentiation factor 15, Macrophage inhibitory cytokine-1 (MIC-1)

This product is for Laboratory Research Use Only not for diagnostic and therapeutic purposes or any other purposes.

CAT: GR175086 Categories: , , Tag:
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Description

Genorise Recombinant Monkey GDF-15 Protein Summary

Alternative names for GDF-15: Growth differentiation factor 15, Macrophage inhibitory cytokine-1 (MIC-1)

Alternative name for monkey: monkey

Product Specifications

Purity > 97%, by SDSPAGE under reducing conditions and visualized by silver stain.
Endotoxin Level < 0.1 EU per 1 μg of the protein by the LAL method.
Activity na
Source E. coli derived monkey GDF-15.
Accession # G7PWZ3
N-Terminal Sequence Analysis Ala
Amino Acid Sequence Ala29-Val308
Predicted Molecular Mass 31 kDa
SDS-PAGE 31 kDa, reducing conditions

 

Background: 

Growth/differentiation factor 15 (GDF15) was first identified as Macrophage inhibitory cytokine-1 or MIC-1.[1] [2] It is a protein belonging to the transforming growth factor beta superfamily. Under normal conditions, GDF-15 is expressed in low concentrations in most organs and upregulated because of injury of organs such as such as liver, kidney, heart and lung.[3][4] The function of GDF-15 is not fully cleared but is seems to have a role in regulating inflammatory pathways and to be involved in regulating apoptosis, cell repair and cell growth, which are biological processes observed in cardiovascular and neoplastic disorders.[3][5] GDF-15 protects the heart from ischemia/reperfusion injury.[6] GDF-15 has shown to be a strong prognostic protein in patients with different diseases such as heart diseases and cancer.[7]

References

  1. Bootcov MR, et al. (1997). Proc National Academy Sci USA. 94 (21): 11514–9.
  2. Ago T, Sadoshima J (2006). Circulation Research. 98 (3): 294–7.
  3. Zimmers TA, et al. (2005). Shock. 23 (6): 543–8.
  4. Hsiao EC, et al. (2000). Molecular and Cellular Biology. 20 (10): 3742–51.
  5. Wollert KC, et al. (2007). Circulation. 116 (14): 1540–8.
  6. Kempf T, et al. (2006). Circulation Research. 98 (3): 351–60.
  7. Wallentin L, et al. (2013). PLOS One. 8 (12): e78797.

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