Description

Genorise Recombinant Canine TNFRII Protein Summary

Alternative names for TNFRII:  tumor necrosis factor receptor II

Alternative name for canine: Dog

Product Specifications

Background: 

A tumor necrosis factor receptor (TNFR), or death receptor, is a trimeric^[2] cytokine receptor that binds tumor necrosis factors (TNF).^[1] The receptor cooperates with an adaptor protein (such as TRADD, TRAF, RIP), which is important in determining the outcome of the response (e.g. apoptosis, inflammation). Because “TNF” is often used to describe TNF alpha, “TNFR” is often used to describe the receptors that bind to TNF alpha – namely, CD120. However, there are several other members of this family that bind to the other TNFs.^[3][4] while all cell types studied express TNF RI, TNF RII expression is limited primarily to hematopoietic cells and cells of the immune system. Most of the biological function of TNF are mediated via TNF RI. Soluble forms of both TNF RI and TNF RII, generated as a result of proteolytic cleavage of the extracellular domain, have been detected in vivo in various fluids. The soluble TNF receptors can bind TNF with high affinity and function as TNF-antagonists. ^{[3, 5-7]}

Reference

1. Banner DW, D’Arcy A, Janes W et al. (May 1993). Cell 73 (3): 431–45.
2. Ashkenazi, A.; Dixit, VM (1998). Science 281 (5381): 1305–8.
3. Locksley RM, Killeen N, Lenardo MJ (2001). Cell 104 (4): 487–501.
4. Hehlgans T, Pfeffer K (2005). Immunology 115 (1): 1–20.
5. Chen G & DV Goeddel (2002) Science 296: 1634.
6. MacEwan DJ (2002) Cell Signal 14: 477.
7. Feldmann M & RN Maini (2001) Annu. Rev. Immunol. 19:163.

Product Citations