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Recombinant Canine Neurotrophin 4 Protein

Nori Canine COX-2 ELISA Kit
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DataSheet   

The recombinant canine neurotrophin 4 protein is derived from in vivo expression of canine NTF4 gene in E. coli and purified using his-tag affinity column and can be used in multiple applications such as cell culture, ELISA and western blot.

Alternative names for neurotrophin 4: NT-4, NT-5, NTF4.

This product is for Laboratory Research Use Only not for diagnostic and therapeutic purposes or any other purposes.

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Description

Genorise Recombinant Canine Neurotrophin 4 Protein Summary

Alternative names for neurotrophin 4: NT-4, NT-5, NTF4.

Alternative name for canine: Dog

Product Specifications

Purity > 97%, by SDSPAGE under reducing conditions and visualized by silver stain.
Endotoxin Level < 0.01 EU per 1 μg of the protein by the LAL method.
Activity Measured in a cell proliferation assay using BaF mouse pro­B cells transfected with TrkB. The ED50 for this effect is 0.4-­3 ng/mL.
Source E. coli derived canine NT-4.
Accession # A0A8C0PL35
N-Terminal Sequence Analysis Leu
Amino Acid Sequence Leu37-Ser156
Predicted Molecular Mass 13 kDa
SDS-PAGE 13 kDa, reducing conditions

 

Background: 

Neurotrophin-4 (NT-4), also known as neurotrophin-5 (NT-5), is a protein that is encoded by the NTF4 gene.[1] It is a neurotrophic factor that signals predominantly through the TrkB receptor tyrosine kinase. Neurotrophin-4 is a novel neurotrophic factor that activates trk and trkB.[2] Neurotrophins and their receptors stimulate melanoma cell proliferation and migration.[3] Increased serum neurotrophin-4/5 levels was observed in bipolar disorder.[4] Elevated intra-amniotic levels of docosahexaenoic acid and arachidonic acid in the mid-trimester are correlated with increased NT4 concentrations.[5]

References

  1. Ip NY et al. (1992) Proc. Natl. Acad. Sci. U.S.A. 89 (7), 3060-3064.
  2. Berkemeier LR, et al. (1991) Neuron 7 (5), 857-866.
  3. Truzzi F, et al. (2008). J. Invest. Dermatol. 128(8): 2031–40.
  4. Walz JC, et al. (2009). J Psychiatr Res. 43 (7): 721–3.
  5. Benn K et al. (2014) Reprod Sci 21 (11), 1395-1400.

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