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Recombinant Bovine BMP7 Protein

Nori Bovine GLUT1 ELISA Kit
Placeholder Recombinant Sheep IL-7 Protein
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DataSheet   

The recombinant bovine BMP7 protein is derived from in vitro expression of bovine BMP7 gene in E. coli and purified using his-tag affinity column and can be used in multiple applications such as cell culture, ELISA and western blot.

Alternative names for BMP7: Bone morphogenetic protein 7, osteogenic protein-1 (OP-1)

This product is for Laboratory Research Use Only not for diagnostic and therapeutic purposes or any other purposes.

CAT: GR104073 Categories: ,
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Description

Genorise Recombinant Bovine BMP7 Protein Summary

Alternative names for BMP7: Bone morphogenetic protein 7, osteogenic protein-1 (OP-1)

 

Product Specifications

Purity > 95%, by SDSPAGE under reducing conditions and visualized by silver stain.
Endotoxin Level < 1.0 EU per 1 μg of the protein by the LAL method.
Activity Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. Nakamura, K. et al. (1999) Exp. Cell Res. 250:351.

Background: 

Bone morphogenetic protein 7 (BMP7, also known as osteogenic protein-1 or OP-1) is a protein that in humans is encoded by the BMP7 gene[1] and belong to BMP family and the TGF-β superfamily. Like other members of the BMP family of proteins, it plays a key role in the transformation of mesenchymal cells into bone and cartilage. It is inhibited by noggin and a similar protein, chordin, which are expressed in the Spemann-Mangold Organizer. BMP7 may be involved in bone homeostasis. It is expressed in the brain, kidneys and bladder.[2] BMP7 induces the phosphorylation of SMAD1 and SMAD5, which in turn induce transcription of numerous osteogenic genes.[3] It has been demonstrated that BMP7 treatment is sufficient to induce all of the genetic markers of osteoblast differentiation in many cell types.[2] Human recombinant BMP7 has surgical uses and is marketed under the brand name OP1. It can be used to aid in the fusion of vertebral bodies to prevent neurologic trauma.[4] Also in the treatment of tibial non-union, frequently in cases where a bone graft has failed.[5] BMP7 also has the potential for treatment of chronic kidney disease.[6][7] BMP7 administration has been proposed as a possible treatment for human infertility.[8] It was discovered that mice injected with BMP7 increased their production of “good” brown fat cells.[9]

References

  1. Hahn GV, et al. (November 1992). Genomics 14 (3): 759–62.
  2. Chen D, et al. (December 2004). Growth Factors 22 (4): 233–41.
  3. Freedman BI, et al. (2009). J. Bone Miner. Res. 24 (10): 1719–27.
  4. Reddi AH (2000). Pediatr. Nephrol. 14 (7): 598–601
  5. Gautschi OP, et al. (2009). J Musculoskelet Neuronal Interact 9 (1): 53–60.
  6. Elshaier AM, et al. (2009). Arthritis Rheum. 60 (1): 143–54.
  7. Yerges LM, et al. (2009). J. Bone Miner. Res. 24 (12): 2039–49.
  8. Dudas PL, et al. (2009). Nephrol. Dial. Transplant. 24 (5): 1406–16.
  9. Sengle G, et al. (2008). J. Mol. Biol. 381 (4): 1025–39.

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