GENORISE SCIENTIFIC, INC.
GENORISE SCIENTIFIC, INC.
PO Box 70
Glen Mills, PA 19342 USA
info@genorise.com
Tel: 610-999-3741; Fax: 610-558-4786
CONTACT
Provides biological reagents and services
Testimonial
Testimonial 2
From: Kathleen Hoover <khoover@uga.edu>
To: "info@genorise.com" <info@genorise.com>
Sent: Thursday, June 11, 2015 12:34 PM
Subject: Lot # request

Hi Jimmy
Recently we ordered and acquired a canine recombinant PDGF-BB
protein.  Catalog number GR104255.  The PO would have been
E245764 shipped on 6/3/15.
The protein has worked great.
I want to record the lot number for that protein.
Thanks!

Kathy
Kathleen Hoover
Testimonial 1:
Nori Equine IL-6 ELISA kit is proven superior to other brands
Testimonial 4
Genorise strives to promote customer service to meet the goal.

From: Nicholas Parkinson <nickp32@vt.edu>
To: Genorise Scientific <info@genorise.com>
Sent: Tuesday, March 15, 2016 12:27 PM
Subject: Re: Technical query regarding ELISA kits

Hi,

I just wanted to confirm that the ELISA kits worked better this time
around. The TNF-alpha kit had slightly lower color development than
previously, but it worked well enough to give me meaningful data. The
IL-6 kit worked beautifully for the standards this time - we still had
problems getting it to work with our samples, but that seemed to be an
issue with our samples rather than any problem with the assay itself.

Thanks,

Nick Parkinson
Testimonial 3
From: Diana Marteles <diana.martelesaragues@gmail.com>
To: Genorise Scientific <info@genorise.com>
Sent: Monday, April 18, 2016 5:56 AM
Subject: Re: Your inquiry

Hi Jimmy,
The Equine TGF beta 1 and IL-10 ELISA kits worked really good. We are
planning to order more of these kits but I need 2-3 days for thinking how
many kits we are going to order and will let you know in a few days.
Thanks a lot,
Diana
Universidad de Zaragoza
Facultad de Veterinaria
Department of Animal Pathology
Miguel Servet 177
50013-Zaragoza
Spain
Testimonial 5
Genorise thrives to provide high quality of products.

From: Wunder Christian <Christian.Wunder@curie.fr>
To: "info@genorise.com" <info@genorise.com>
Sent: Tuesday, May 16, 2017 6:03 AM
Subject: Re: Delivery problem monkey EFG (ref GR175075 x2)
Purchase oder # 2-04470

Dear Jimmy,
The ordered monkey EGF works perfect on our cells. Thanks.
Please, could you send me the sequence/ database number of the
monkey EGF you are purifying?
Thanks again,

Christian
Genorise products are cited in "Nature" article

Title: Progesterone prevents epithelialmesenchymal transition of ovine amniotic epithelial cells and enhances their immunomodulatory properties
Published at: Nature, 19-Jun-17, doi:10.1038/s41598-017-03908-1.
Authors: Angelo Canciello 1, Valentina Russo1, Paolo Berardinelli1, Nicola Bernabò1, Aurelio Muttini1, Mauro Mattioli2 & Barbara Barboni1
1Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Via Renato Balzarini 1, 64100, Teramo, Italy. 2Istituto Zooprofilattico
Sperimentale dell’Abruzzo e del Molise (IZSAM) “G. Caporale”, Campo Boario, 64100, Teramo, Italy. Correspondence and requests for materials should be addressed to A.C.
(acanciello@unite.it).

The in vitro expansion is detrimental to therapeutic applications of amniotic epithelial cells (AEC), an emerging source of fetal stem cells. This study provides molecular
evidences of progesterone (P4) role in preventing epithelial-mesenchymal transition (EMT) in ovine AEC (oAEC). oAEC amplified under standard conditions spontaneously
acquired mesenchymal properties through the up-regulation of EMT-transcription factors. P4 supplementation prevented phenotype shift by inhibiting the EMT inducing
mechanism such as the autocrine production of TGF-β (quantified by Nori Sheep TGF-β3 ELISA Kit, Genorise Scientific, Inc.) and the activation of intracellular related signaling.
The effect of P4 still persisted for one passage after steroid removal from culture as well as steroid supplementation promptly reversed mesenchymal phenotype in oAEC which
have experienced EMT during amplification. Furthermore, P4 promoted an acute up-regulation of pluripotent genes whereas enhanced basal and LPS-induced oAEC anti-
inflammatory response with an increase in anti-inflammatory (quantified by Nori Sheep IL-4 and IL-10 ELISA Kits, Genorise Scientific, Inc.) and a decrease in pro-inflammatory
cytokines expression. Altogether, these results indicate that P4 supplementation is crucial to preserve epithelial phenotype and to enhance biological properties in expanded
oAEC. Therefore, an innovative cultural approach is proposed in order to improve therapeutic potential of this promising source of epithelial stem cells.

The present research has been designed to assess the effects of P4 supplementation during AEC amplification. The results confirmed the effective influence of P4 in preserving
the oAEC
epithelial phenotype. Indeed, P4 inhibited EMT pathway by preventing TGF-β secretion and by modulating EMT-related intracellular mechanisms. Noteworthy, P4-treated oAEC
that preserved epithelial phenotype also displayed greater biological properties. In particular, oAEC acutely up-regulated stemness gene expression after P4 supplementation
while enhanced their immunomodulatory properties, two functions, which are both crucial to impact on AEC regenerative potential.

Read full-length article here
Testimonial 6
Genorise thrives to provide consistent quality of products and retain old
customers.

From: "Witonsky, Sharon" <switonsk@vt.edu>
To: 'Genorise Scientific' <account@genorise.com>; "Price, Lovie"
<loprice@vt.edu>
Cc: "Smith, Tracie" <cvmtps@vt.edu>; Genorise Scientific
<support@genorise.com>
Sent: Tuesday, February 27, 2018 8:03 AM
Subject: RE: Invoice Credit (P3313616)

Thank you Jimmy.
I have only run the IL-6 serum and CSF kits so far, but the kits seem to
work well.
I will definitely continue to use Genorise as the projects and funds dictate.
Sharon