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Recombinant Canine AMH Protein

Nori Canine COL1A1 ELISA Kit
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DataSheet   

The recombinant canine AMH protein is derived from in vitro expression of canine AMH gene in E. coli and purified using his-tag affinity column and can be used in multiple applications such as cell culture, ELISA and western blot.

Alternative names for AMH: Anti-Müllerian hormone, Müllerian-inhibiting hormone (MIH), MIS

This product is for Laboratory Research Use Only not for diagnostic and therapeutic purposes or any other purposes.

CAT: GR122127 Categories: ,
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Description

Genorise Recombinant Canine AMH Protein Summary

Alternative names for AMH: Anti-Müllerian hormone, Müllerian-inhibiting hormone (MIH), MIS

Alternative name for canine: dog

Product Specifications

Purity > 95%, by SDSPAGE under reducing conditions and visualized by silver stain.
Endotoxin Level < 0.1 EU per 1 μg of the protein by the LAL method.
Activity NA
Source E. coli derived canine AMH.
Accession # NP_001301056.1
N-Terminal Sequence Analysis Ala
Amino Acid Sequence Ala436 –Arg572
Predicted Molecular Mass 15 kDa
SDS-PAGE 15 kDa, reducing conditions

 

Background: 

Anti-Müllerian hormone (AMH), also known as Müllerian-inhibiting hormone (MIH), is a glycoprotein hormone structurally related to inhibin and activin from the transforming growth factor beta superfamily, whose key roles are in growth differentiation and folliculogenesis. AMH is activated by SOX9 in the Sertoli cells of the male fetus.[1] Its expression inhibits the development of the female reproductive tract, or Müllerian ducts, in the male embryo, thereby arresting the development of fallopian tubes, uterus, and upper vagina.[2] AMH expression is critical to sex differentiation at a specific time during fetal development, and appears to be tightly regulated by nuclear receptor SF-1, transcription GATA factors, sex-reversal gene DAX1, and follicle-stimulating hormone (FSH).[3][4] Mutations in both the AMH gene and the type II AMH receptor have been shown to cause the persistence of Müllerian derivatives in males that are otherwise normally masculinized. AMH is also a product of granulosa cells of the preantral and small antral follicles in women. As such, AMH is only present in the ovary until menopause. Production of AMH regulates folliculogenesis by inhibiting recruitment of follicles from the resting pool in order to select for the dominant follicle, after which the production of AMH diminishes.[5] AMH can also serve as a biomarker for relative size of the ovarian reserve.[6] In bovine, AMH can be used for selection of females in multi-ovulatory embryo transfer programs by predicting the number of antral follicles developed to ovulation.[7] AMH can also be used as a marker for ovarian dysfunction, such as in women with polycystic ovary syndrome (PCOS).

References

  1. Taguchi O, et al. (1984). Developmental Biology. 106 (2): 394–8.
  2. Panidis D, et al. (2011). Medical Hypotheses. 77 (4): 649–53.
  3. Shen WH, et al. (1994) Cell. 77 (5): 651–61.
  4. Viger RS, et al. (1998). Development. 125 (14): 2665–75.
  5. Kollmann Z, et al. (2015). Reproductive Biology and Endocrinology. 13: 21.
  6. Weenen C, et al. (2004). Molecular Equine Reproduction. 10 (2): 77–83.
  7. Rico C, et al. (2011). Biology of Reproduction. 84 (3): 560–71.

 

 

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