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Recombinant Bovine TGFb2 Protein

Nori Bovine IL-12 p35 ELISA Kit
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DataSheet   

The recombinant bovine TGFb2 protein is derived from in vitro expression of bovine TGFb2 gene in E. coli and purified using his-tag affinity column and can be used in multiple applications such as cell culture, ELISA and western blot.

Alternative names for TGFb2: transforming growth factor beta 2

This product is for Laboratory Research Use Only not for diagnostic and therapeutic purposes or any other purposes.

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Description

Genorise Recombinant Bovine TGFb2 Protein Summary

Alternative names for TGFb2: transforming growth factor beta 2

Alternative name for bovine: cow, cattle, bull

Product Specifications

Purity > 96%, by SDSPAGE under reducing conditions and visualized by silver stain.
Endotoxin Level < 1.0 EU per 1 μg of the protein by the LAL method.
Activity Measured by its ability to inhibit the IL-4-dependent proliferation of HT-2 mouse T cells. Tsang, M et al. (1995) 7:389. The ED50 for this effect is typically 25-250 pg/mL.
Source E. coli derived bovine TGFb2
Accession # NP_001106723.1
N-Terminal Sequence Analysis Ala
Amino Acid Sequence Ala303 –Ser414
Predicted Molecular Mass 12.7 kDa
SDS-PAGE 12.7 kDa, reducing conditions

 

Background: 

TGF-β2 (Transforming growth factor-beta 2) is a secreted protein known as a cytokine that performs many cellular functions and has a vital role during embryonic development (alternative names: Glioblastoma-derived T-cell suppressor factor, G-TSF, BSC-1 cell growth inhibitor, Polyergin, Cetermin). It is an extracellular glycosylated protein. It is known to suppress the effects of interleukin dependent T-cell tumors.

TGFB1, TGFB2, and TGFB3 all function through the same receptor signaling systems. They are members of the large TGFβ superfamily. TGFβ proteins are highly pleiotropic cytokines that regulate processes such as immune function, proliferation and epithelialmesenchymal transition (1-3). TGFβ activation from latency is controlled both spatially and temporally, by multiple pathways that include actions of proteases such as plasmin and MMP9, and/or by thrombospondin 1 or selected integrins (4). The active form of TGFβ2 is a disulfidelinked homodimer which is generated by activation of the latent TGFβ2 complex. TGFβs are multifunctional cytokines that activate or repress multiple genes in a wide variety of cell types. Depending on the cell context, TGFβ can control many cellular processes including growth, morphogenesis, and apoptosis.

References

  1. Dunker, N. and K. Krieglstein (2000) Eur. J. Biochem.267:6982.
  2. Wahl, S.M. (2006) Immunol. Rev. 213:213.
  3. Chang, H. et al. (2002) Endocr. Rev. 23:787.
  4. Oklu, R. and R. Hesketh (2000) Biochem. J. 352:601.

 

 

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