Description

Genorise Recombinant Equine IL-10 Protein Summary

Alternative names for IL-10: interleukin 10, IL10, CSIF, cytokine synthesis inhibitory factor

Alternative name for equine: horse

Product Specifications

Background: 

IL-10, also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine that is produced by T cells, NK cells, mast cells and macrophages (1,2,3). It is capable of inhibiting synthesis of pro-inflammatory cytokines like IFN-γ, IL-2, IL-3, TNFα and GM-CSF made by cells such as macrophages and regulatory T-cells. IL-10 also displays potent abilities to suppress the antigen presentation capacity of antigen presenting cells. IL-10 initiates signal transduction by binding to a cell surface receptor complex consisting of IL-10 RI and IL-10 RII (1). Binding of IL-10 leads to the activation of Jak1 and Tyk2, which phosphorylates Stat-3 (1,4). The anti-inflammatory activity of IL-10 is due to its ability to block signaling through other cytokine receptors, notably IFNγ receptor, by upregulating expression of SOCS-1 (1,4). In addition, IL-10 promotes T cell tolerance by inhibiting tyrosine phosphorylation of CD28 (5,6). IL-10 is an important negative regulator of the immune response, which allows for maintenance of pregnancy (1). In contrast, increased IL-10 levels contribute to persistent Leishmania major infections (7).

References

1. Pestka, S. et al. (2004) Immunol Rev 202, 8-32.
2. Akuffo, H. et al. (1999) Clin Exp Immunol 117, 529-34.
3. Grimbaldeston MA, et al (2007). Nat. Immunol. 8 (10): 1095–104.
4. O’Shea, J.J. and Murray, P.J. (2008) Immunity 28, 477-87.
5. Akdis, C.A. and Blaser, K. (2001) Immunology 103, 131-6.
6. Akdis, C.A. et al. (2000) FASEB J 14, 1666-8.
7. Von Stebut, E. (2000) Eur J Dermatol 17, 115-22.

Product Citations