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Recombinant Equine BMP2 Protein

Nori Equine IgM ELISA Kit
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DataSheet   

The recombinant equine BMP2 protein is derived from in vitro expression of equine BMP2 gene in Chinese Hamster Ovary cell and purified using his-tag affinity column and can be used in multiple applications such as cell culture, ELISA and western blot.

Alternative names for BMP2: Bone morphogenetic protein 2

This product is for Laboratory Research Use Only not for diagnostic and therapeutic purposes or any other purposes.

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Description

Genorise Recombinant Equine BMP2 Protein Summary

Alternative names for BMP2: Bone morphogenetic protein 2

Alternative name for equine: horse

Product Specifications

Purity > 96%, by SDSPAGE under reducing conditions and visualized by silver stain.
Endotoxin Level <1.0 EU per 1 μg of the protein by the LAL method.
Activity Measured in its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. Binnerts ME. et al (2004) Biochem Biophys Res Commun 315:272. The ED50 for this effect is typically 50-150 ng/mL.
Source Chinese Hamster Ovary cell derived equine BMP2.
Accession # F6T889
N-Terminal Sequence Analysis Gln
Amino Acid Sequence Gln283-Arg396
Predicted Molecular Mass 13 kDa
SDS-PAGE 13 kDa, reducing conditions

 

Background: 

Bone morphogenetic protein 2 or BMP-2 belongs to the TGF-β superfamily of proteins (1). BMP-2 has been shown to interact with BMPR1A. BMP-2 like other bone morphogenetic proteins (2) plays an important role in the development of bone and cartilage. It is involved in the hedgehog pathway, TGF beta signaling pathway, and in cytokine-cytokine receptor interaction. It is involved also in cardiac cell differentiation and epithelial to mesenchymal transition.BMP-2 and BMP-7 are osteoinductive BMPs: they have been demonstrated to potently induce osteoblast differentiation in a variety of cell types (3). 

References

  1. Sampath TK, et al. (5 August 1990). J. Biol. Chem. 265 (22): 13198
  2. Chen D, et al. (December 2004). Growth Factors 22 (4): 233
  3. Marie PJ, et al. (2002). Histol. Histopathol. 17 (3): 877

 

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