Recombinant Equine Artemin Protein

$99.00$730.00

DataSheet   

The recombinant equine artemin protein is derived from in vivo expression of equine artemin gene in E. coli and purified using his-tag affinity column and can be used in multiple applications such as cell culture, ELISA and western blot.

Alternative names for artemin: enovin, neublastin

This product is for Laboratory Research Use Only not for diagnostic and therapeutic purposes or any other purposes.

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Description

Genorise Recombinant Equine Artemin Protein Summary

Alternative names for artemin: enovin, neublastin

 

Product Specifications

Purity > 97%, by SDSPAGE under reducing conditions and visualized by silver stain.
Endotoxin Level < 0.1 EU per 1 μg of the protein by the LAL method.
Activity Measured in a cell proliferation assay using TF-1 human erythroleukemic cells.
Source E. coli derived equine artemin.
Accession # A0A9L0RDA4
N-Terminal Sequence Analysis Ala
Amino Acid Sequence Ala37-Cys156
Predicted Molecular Mass 13 kDa
SDS-PAGE 13 kDa, reducing conditions

 

Background: 

Artemin, also known as enovin or neublastin, is a protein that is encoded by the ARTN gene.[1] Artemin is a neurotrophic factor in the glial cell line-derived neurotrophic factor family of ligands which are a group of ligands within the TGF-beta superfamily of signaling molecules. GDNFs are unique in having neurotrophic properties and have potential use for gene therapy in neurodegenerative disease. Artemin has been shown in culture to support the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. Its role in the PNS and CNS is further substantiated by its expression pattern in the proximity of these neurons. This protein is a ligand for the RET receptor and uses GFR-alpha 3 as a coreceptor. Artemin could promote the proliferation and invasiveness of lung cancer cells in vitro and therefore could be a new potential target to combat lung cancer.[2] Artemin regulates CXCR4 expression to induce migration and invasion in pancreatic cancer cells through activation of NF-kappaB signaling.[3] ARTN and MMP-9 are involved in the occurrence, development, invasion and metastasis of EC, and play a synergistic role in the development of EC and lymphatic metastasis.[4] AhR activation and ARTN expression were positively correlated in the epidermis of patients with atopic dermatitis.[5]

References

  1. Baloh RH, et al. (1998). Neuron. 21 (6): 1291–302.
  2. Song Z,et al. (2018) Thorac Cancer 9 (5), 555-562.
  3. Wang J, et al. (2018) Exp. Cell Res. 365 (1), 12-23.
  4. Wang XH, et al. (2017) J. Biol. Regul. Homeost. Agents 31 (4), 879-887.
  5. Hidaka T, et al. (2017) Nat. Immunol. 18 (1), 64-73.

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