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Recombinant Monkey IL-6R Protein

Placeholder Recombinant Monkey NGF-B
Placeholder Recombinant Equine TNFa Protein
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DataSheet   

The recombinant monkey IL-6R protein is derived from in vivo expression of monkey IL-6R gene in E. coli and purified using his-tag affinity column and can be used in multiple applications such as cell culture, ELISA and western blot.

Alternative names for IL-6R: Interleukin 6 receptor, IL6R

This product is for Laboratory Research Use Only not for diagnostic and therapeutic purposes or any other purposes.

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Description

Genorise Recombinant Monkey IL-6R Protein Summary

Alternative names for IL-6R: Interleukin IL-6 receptor, IL6R

 

Product Specifications

Purity > 97%, by SDSPAGE under reducing conditions and visualized by silver stain.
Endotoxin Level < 0.1 EU per 1 μg of the protein by the LAL method.
Activity na
Source E. coli derived monkey IL-6R.
Accession # XP_001114404
N-Terminal Sequence Analysis Leu
Amino Acid Sequence Leu20-Ser359
Predicted Molecular Mass 37 kDa
SDS-PAGE 37 kDa, reducing conditions

 

Background: 

Interleukin 6 receptor (IL6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. In melanocytic cells IL6R gene expression may be regulated by MITF.[1] The IL6 receptor is a protein complex consisting of a IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. IL6R also denotes the human gene encoding this subunit. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[2] IL6R subunit is also shared by many other cytokines. Interleukin-6 receptor has been shown to interact with Interleukin 6[2] [3] [4] and Ciliary neurotrophic factor.[3][5]

Reference

  1. Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). Pigment Cell Melanoma Res. 21 (6): 665–76.
  2. Schwantner, Andreas et al. (2004) J. Biol. Chem. 279 (1): 571–6.
  3. Schuster, Björn et al. (2003) J. Biol. Chem. 278 (11): 9528–35.
  4. Taga, T et al. (1989) Cell 58 (3): 573–81.
  5. Schooltink, H (1992) FEBS Lett. 314 (3): 280–4.

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