Description

Genorise Recombinant Rabbit IL-15 Protein Summary

Alternative names for IL-15: Interleukin IL-15, IL15

Product Specifications

Background: 

Interleukin 15 (IL-15) is a cytokine with structural similarity to IL-2. Like IL-2, IL-15 binds to and signals through the IL-2/IL-15 beta chain (CD122) and the common gamma chain (gamma-C, CD132) (1, 2, 3). IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus. Interleukin 15 (IL-15) regulates T and natural killer (NK) cell activation and proliferation. Survival signals that maintain memory T cells in the absence of antigen are provided by IL-15. This cytokine is also implicated in NK cell development. IL-15 receptor, which binds IL-15 propagates its function. Some subunits of the IL-15 receptor are shared in common with the receptor for a structurally related cytokine called interleukin 2 (IL-2) allowing both cytokines to compete for and negatively regulate each other’s activity (4, 5). CD8+ memory T cell number is controlled by a balance between IL-15 and IL-2. When IL-15 binds its receptor, JAK kinase, STAT3, STAT5, and STAT6 transcription factors are activated to elicit downstream signaling events.

References

1. 1. Grabstein, K. et al. (1994) Science 264:965.
   2. Budagian, V. et al. (2006) Cytokine Growth Factor Rev.17:259.
   3. Ma, A. et al. (2006) Annu. Rev. Immunol. 24:657.
   4. Giri, J. et al. (1994) EMBO J. 13:2822.
   5. Duitman, E.H. et al. (2008) Mol. Biol. 28:4851.

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