Genorise Recombinant Canine IL-3 Protein Summary

Alternative names for IL-3: Interleukin 3, IL3, MCGF

Alternative name for canine: Dog

Product Specifications

Background: 

Interleukin 3 (IL-3) is a protein that is encoded by the IL3 gene^[1] and it is called colony-stimulating factor; mast cell growth factor, MULTI-CSF, MCGF; MGC79398, MGC79399. The protein contains 152 amino acids and its molecular weight is 17 kDa and the naturally occurring IL-3 is glycosylated. IL-3 is produced as a monomer by activated T cells, monocytes/macrophages and stroma cells. The major function of IL-3 cytokine is to regulate blood-cell production. It induces proliferation and differentiation of early pluripotent stem cells and committed progenitors.^[2] Interleukin 3 acts by binding to the interleukin-3 receptor.^[3] IL-3/Receptor complex induces JAK2/STAT5 cell signalisation pathway. It can stimulate transcription factor c‑myc (activation of gene expression) and Ras pathway (suppression of apoptosis). Interleukin 3 has been shown to interact with IL3RA.^[4] Interleukin 3 stimulates the differentiation of multipotent hematopoietic stem cells into myeloid progenitor cells or, with the addition of IL-7, into lymphoid progenitor cells. In addition, IL-3 stimulates proliferation of all cells in the myeloid lineage (granulocytes, monocytes, and dendritic cells), in conjunction with other cytokines, e.g., Erythropoietin (EPO), Granulocyte macrophage colony-stimulating factor (GM-CSF), and IL-6. It is secreted by basophils and activated T cells to support growth and differentiation of T cells from the bone marrow in an immune response.

References

1. Yang YC, et al. (1986). Cell. 47 (1): 3–10. doi:1016/0092-8674(86)90360-0. PMID3489530.
2. Aglietta, M.; et al. (1996). Stem Cells. 11 (S2): 83–87.
3. Tabira T, et al. (1998). Ann. N. Y. Acad. Sci. 840 (1): 107–16.
4. Stomski FC, et al. (1996). Mol. Cell. Biol. 16 (6): 3035–46.